Miyazawa Y, Murayama T, Ooya N, et al. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Norman JA, Pickford CJ, Sanders TW, Waller M. Human intake of arsenic and iodine from seaweed-based food supplements and health foods available in the UK. That said, all improvements were subjective [51]. Int.Immunopharmacol. Allergy 1990;45(7):481-486. C. vulgaris enhanced cell-mediated immunity (Th1 response) in mice allergic to casein. Moreover, the water extract of Chlorella boosted the production of stem cells in the bone marrow and spleen, which increased the survival of mice after being irradiated with gamma rays [70]. Chlorella and spirulina are safe to be taken as whole food supplements, but some consumers have reported mild reactions. these proteins induce cell death [58]. The same person previously practiced long-term spirulina supplementation with no side effects. Photo: How do you avoid Chlorella side effects..? New phytophotodermatosis. High levels of cholesterol or other fats (lipids) in the blood (, Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic. Today, Chlorella is being used in Japan, the USA, Europe, and other countries. View abstract. If you are worried about the side effects of doing a heavy metal detox using supplements such as cilantro and chlorella, you are not alone. These are even more likely with a higher dosage or when you first include them in your diet. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. The interest in Chlorella production began in the 1960s when a Japanese company started to culture it on a massive scale, and by 1980 the production spread in Asia, reaching more than 1,000 kg of produced microalga (mainly Chlorella) per month [3]. Kralovec, J. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health and prepare his body to fight off infections. Another user was building up from 1 to 5 tablets per day and reported good detox results with no side effects. View abstract. Common side effects include bone marrow suppression, nausea, and diarrhea. Cheng, F. C., Lin, A., Feng, J. J., Mizoguchi, T., Takekoshi, H., Kubota, H., Kato, Y., and Naoki, Y. Do not consider user experiences as medical advice. 2002;2(4):579-589. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. A trial of 6 individuals revealed that Chlorella consumed for 2 weeks decreased urine levels of a cancer-causing heterocyclic amine [37]. View abstract. Peirce A. Higher levels of IgA in breast milk helps reduce the risk of infection in nursing infants [25]. ^ a b Nakashima Y, et al. Intense exercise can weaken the immune system. View abstract. Stomach cramps. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Chlorella side effects can be mistaken for mercury toxicity symptoms from Herxheimer effect during detox. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]. Early research shows that taking chlorella extract tablets for 6 weeks, in addition to already prescribed, Airway infections caused by exercise. But chlorella does not seem to slow the progression of the cancer or improve survival. It protected mice from E. coli and Listeria monocytogenes infection in two animal trials [26, 27]. View abstract. To reduce the risk of side effects treatment duration should be as short as possible. C. pyrenoidosa improved breast cancer in mice by suppressing its growth [57]. Ryu NH, Lim Y, Park JE, et al. 2001;67(8):737-742. Additional side effects may include fatigue, irritability and increased sensitivity to sun exposure. People respond differently to diets and supplements because everyone has unique DNA. J Nutr 1995;125:2511-5. … The American Pharmaceutical Association Practical Guide to Natural Medicines. Some people may experience uncomfortable side effects after ingesting even a small amount of these plants – while others breeze through the detox without so much as a headache. Neurosci Lett. It had a more potent activity than tomato lycopene [10]. All of our content is written by scientists and people with a strong science background. The researchers also found that the chlorella resulted in no negative side effects among the patients. They should guide further investigation but shouldn’t be interpreted as supportive of the anticancer effects until more research is done. Halperin SA, Smith B, Nolan C, et al. Proteins, selenium and sulphur-containing amino acids are also helpful in combating mercury. 1978;43(4):271-273. Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. There are no major (life-threatening) side effects associated with chlorella. (check all that apply), What factors are most important to you? Early research shows that taking chlorella for 12 weeks improves liver inflammation but does not decrease levels of the hepatitis C virus in the blood. The most common side effects include diarrhea, nausea, gas (flatulence), green discoloration of the stools, and stomach cramping, especially in the two weeks of use. A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder. Tiberg, E., Rolfsen, W., Einarsson, R., and Dreborg, S. Detection of Chlorella-specific IgE in mould-sensitized children. Itching and rash 13. Merchant, R. E., Andre, C. A., and Sica, D. A. Nutritional supplementation with Chlorella pyrenoidosa for mild to moderate hypertension. Chlorella might increase the immune system. The same conce… Ng, T. P., Tan, W. C., and Lee, Y. K. Occupational asthma in a pharmacist induced by Chlorella, a unicellular algae preparation. In a 2-month trial performed in 12 elderly subjects, it decreased oxidative damage to red blood cells by reducing phospholipid hydroperoxide (PLOOH) concentrations, thus enhancing their ability to transport oxygen to the brain [32]. However, in one study, C. vulgaris was unable to increase cadmium excretion in rats fed this heavy metal [46]. Back To TOC. Ichimura, S. [Effect of chlorella on skin cancer of Black Foot patients in south Formosa]. Taken together, the effects of Chlorella on blood sugar, cholesterol, and blood pressure indicate its potential to prevent heart disease, but clinical trials should investigate this further. Fibromyalgia. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Spirulina and liver health go together in a good way and there are clinical studies to back this claim up. Altern.Ther.Health Med. Another study of 15 men, revealed that salivary IgA was increased in participants when they ingested Chlorella tablets for 4 weeks [24]. Written by Carole Beck on December 6, 2018 Reviewed … Some suggest that Chlorella may interfere with immunosuppressive drugs. Panahi Y, Ghamarchehreh ME, Beiraghdar F, Zare R, Jalalian HR, Sahebkar A. View abstract. Align your health hacks with your genes for optimal health & cognitive function. Ruama AL, Torronen R, Hanninen O, Mykkanen H. Vitamin B12 status of long-term adherents of a strict uncooked vegan diet ("living food diet") is compromised. Chlorella interacts with warfarin, by decreasing its anticoagulant effect and increasing platelet aggregation [85, 86]. Chlorella may also cause photosensitivity, increasing the risk of sun rash and sunburn. Early research shows that taking chlorella tablets for 6 weeks might strengthen the. Side Effects of Chlorella ♦ Some people are known to suffer from stomach problems, diarrhea, water retention, flatulence, green discoloration of stool, and nausea. View abstract. A study in pregnant mice revealed how C. pyrenoidosa suppressed methylmercury transfer to the fetus and reduced its accumulation in the mothers’ brains [44]. Chlorella is generally considered safe and well-tolerated. Levels of alanine transaminase (ALT), a marker of liver inflammation, were significantly reduced in 85% of 18 hepatitis C patients treated with C. pyrenoidosa extract for 12 weeks [34]. SelfDecode provides recommendations that are. It may also increase sun sensitivity, especially for those with fair skin. It had a protective effect against carcinogenic heterocyclic amines in rat colon [41]. Dietary Chlorella pyrenoidosa for patients with malignant glioma: effects on immunocompetence, quality of life, and survival. Clinical trials are needed to investigate the potential anticancer effects of Chlorella. In a study of 70 pregnant women, Chlorella supplementation (6 g daily, from the 12th-18th week of pregnancy) reduced the risk of anemia by 48%, compared to control [47]. Very Nutritious. Haidari F, Homayouni F, Helli B, Haghighizadeh MH, Farahmandpour F. Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea. However, one person also experienced severe nausea and vomiting after a few weeks of Chlorella supplementation. Welcome to the final article of our Liver Detox 101 series! Warfarin (Coumadin) is used to slow blood clotting. Nutr Res. Some of the chlorella side effects include: swelling of the face or tongue sensitivity to sunlight digestive upset acne fatigue lethargy headaches vertigo shaking Weakness 9. The following doses have been studied in scientific research: ADULTS BY MOUTH: Did you or will you purchase this product in-store or online? Flatulence 2. Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others. Minor side effects are relatively common and may occur in as many as 18% of consumers. The dose of your warfarin (Coumadin) might need to be changed. C. vulgaris improved physical stamina in mice [49]. J Med Food. Also in mice, C. vulgaris prevented the immunosuppressive effects caused by stress [29]. Detoxification of chlorella supplement on heterocyclic amines in Korean young adults. Chlorella improved the elimination of radioactive strontium from mice through adsorption in the intestines [43]. Diarrhea Most of these side effects tend to resolve as your body adapts to treatment. Chidley C, Davison G. The effect of Chlorella pyrenoidosa supplementation on immune responses to 2 days of intensified training. According to registered data obtained from microalgae consumers, spirulina has a higher rate of adverse events than Chlorella [82]. Some people with fibromyalgia say they feel better when they take chlorella tablets plus a liquid extract containing malic acid daily for 2 months. In a mouse model of Parkinson’s, polysaccharides from C. pyrenoidosa prevented the loss of dopamine and neuron death, inhibited inflammation, improved symptoms, and delayed disease progression [80]. Chlorella is possibly safe during pregnancy, but pregnant women should use it only if prescribed by their doctor [47]. Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets. Dizziness 7. Fever 8. Join SelfHacked today and start the journey of improving your life, Get the Regimen of A Top Biohacker Preparing His Body to Fight Coronavirus, Avoid Illness By Using the Best Supplements For Your Body. View abstract. Hasegawa, T., Matsuguchi, T., Noda, K., Tanaka, K., Kumamoto, S., Shoyama, Y., and Yoshikai, Y. Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris. 2001;7(3):79-91. In a study performed in 38 smokers for 6 weeks, Chlorella reduced the levels of malondialdehyde in the blood, a marker of oxidative stress, and increased blood levels of 7 different antioxidant measures [30]: Furthermore, another 6-week study with 52 smokers revealed that Chlorella powder increased blood levels of vitamin E (alpha-tocopherol) and vitamin C. It also raised the activity of superoxide dismutase and erythrocyte catalase [31]. Hot water extract of C. vulgaris triggered the death of human liver cancer cells by increasing p53, Bax, and caspase-3. On the other hand, spirulina improves hemoglobin, protein, and vitamin levels in malnourished children, increases immune function, has a great antioxidant capacity, and is a good source of beta-carotene [87].